The CIB Margarita Salas is a multidisciplinary institute integrating an array of disciplines in structural and cellular biology, biomedicine, biotechnology, agriculture, environmental sciences, and chemistry, which makes it unique among other CSIC research institutes. CIB-CSIC is leader in Spain in the research and development of new drugs for the treatment of neurological and neglected diseases.
The Translational Medicinal and Biological Chemistry research group has high experience on molecular modelling and chemoinformatics, organic synthesis, biological screening, ADMETox properties optimization and business management. Projects running at the Translational Medicinal and Biological Chemistry Laboratory increase the knowledge on innovative targets with clear therapeutic potential for unmet diseases such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, tripanosiomasis, and allow the discovery of new drug candidates for their treatment.
The research focus is on small heterocyclic molecules with MW<500. The Translational Medicinal and Biological Chemistry Laboratory has developed an in-house chemical library (called MBC library) containing over 2000 compounds with privileged scaffolds, which is continuously growing and extensively used in the directed biological and computational screening programs. Research is applied with a high content of translational research and designed from the early stages of drug discovery to proof of efficacy in representative animal models. Scientific collaborations and technology transfer to companies in the pharmaceutical sector are key tasks.
For more information on the Translational Medicinal and Biological Chemistry Laboratory at Centro de Investigaciones Biologicas- CIB-CSIC in Madrid see here.