Webinar Recordings

Speaker: Victor Wong, PhD, CSO of Core Life Analytics, The Netherlands

EU-OPENSCREEN training webinar on March 28th at 10:00 AM CET will host Victor Wong, PhD, CSO of Core Life Analytics company. His talk on demystifying Data Science for Image-Based Phenotypic Screening will be focused on best-practices data analytics for high content data, and discussion of fundamental principles.

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Speaker: Fernanda Borges, Associate Professor of the Department of Chemistry and Biochemistry of Faculty of Sciences, University of Porto

Fernanda Borges is Associate Professor of the Department of Chemistry and Biochemistry of Faculty of Sciences of University of Porto and the Coordinator of the Medicinal Chemistry Group in Chemistry Research Centre of the University of Porto (CIQUP) one of the EU-OPENSCREEN Portuguese partner sites. Fernanda will talk about mitochondria as a druggable target focusing on the history of mitochondriotropic antioxidants.

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Speaker: Rui Moreira, EFMC President and Group Leader at iMed.ULisboa, Faculty of Pharmacy, University of Lisbon

EU-OPENSCREEN webinar series for 2023 start on January 31st at 10:00 AM CET with the talk of Rui Moreira, EFMC President and Group Leader, iMed.ULisboa, Faculty of Pharmacy, University of Lisbon, Portugal on the strategies in Antimalarial Drug Discovery.

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Speaker: Susanne Müller-Knapp, Chief Operating Officer at the SGC Frankfurt

Our guest for the webinar “Open-Source Chemical Probes for Understanding Cellular Phenotypes” is Susanne Müller-Knapp, Chief Operating Officer at SGC Frankfurt who is now coordinating several chemical probe programs and making these well-characterised tool compounds available to the scientific community. She is also Director of Operations of the Chemical Probes Portal.

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Speaker: Olga Genilloud, (Scientific Director and Area Head Microbiology, Fundación MEDINA, Spain)

Olga Genilloud, Scientific Director of our partner site Fundación MEDINA in Granada, will talk about different strategies that are being implemented at MEDINA to exploit the chemical diversity  and complexity of their natural products’ libraries and the challenges and opportunities  to identify, with a broad array of assay formats and technologies, novel target inhibitors and modulators with application in cancer, immunomodulation, and inflammation  processes.

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Speaker: Brinton Seashore-Ludlow, Head of the assay development and screening team at the Chemical Biology Consortium Sweden

Dr Seashore-Ludlow’s group focuses on drug sensitivity testing of primary patient cells and near-patient models.

In this talk she will present the development of functional precision medicine tools for ovarian cancer.

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Speaker: Professor Jonathan Bayldon Baell, Director of the Australian Translational Medicinal Chemistry Facility

EU-OPENSCREEN is proud to host Jonathan Baell, Director of the Australian Translational Medicinal Chemistry Facility, in the training webinar entitled: “HTS-driven drug discovery: The screening deck quality with proper hit triage is everything” .

Jonathan Baell is also the Theme Leader - Fragment library design for the ARC Industrial Transformation Training Centre and Larkins Fellow, Department of Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, recently ranked #1 in the world by subject. He has more than 25 years of experience in medicinal chemistry-led drug discovery and development, with more than 150 publications and 9000 citations, including first author Nature 2018, and more than 80 granted patents.

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Speaker: Professor Mads Hartvig Clausen, Technical University of Denmark (DTU), Director of DK-OPENSCREEN

EU-OPENSCREEN is proud to host Mads Hartvig Clausen from our partner site Technical University of Denmark.

Mads and his team are involved in the design, synthesis and screening of fragment libraries, as well as hit-to-lead medicinal chemistry. They are interesting in a range of protein target and more recently also RNA targets. Thus, new efforts are focused on the synthetic expansion of our fragment library to include molecules directed towards RNA targets, based on their established screening platform for ¹⁹F-NMR fragment screening with hit validation by ¹H-NMR.

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Speaker: Harald Schwalbe, Director of Instruct ERIC

Integrated structural biology and medicinal chemistry are research areas with large mutual interest, substantial synergies, and need for coordination. At the same time, global challenges require coordinated research approaches on national and international level. European Research Infrastructure Consortia (ERICs) aim at identifying these mutuals interests and required coordination. The new Director of Instruct-ERIC, Harald Schwalbe, will discuss the potentials for collaborations on the example of: Coordinated research towards the development of anti-viral reactive compounds against SARS-CoV-2.

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Speaker: María J. Vicent , CIPF Principe Felipe Research Center, Valencia

María J. Vincent is responsible for the Screening Platform at CIPF, Valencia, one of the Specialist Screening Sites of EU-OPENSCREEN, where she coordinates the Advanced Therapies Program. She is part of the Strategic Committee of the Valencian Agency of Innovation (AVI) and serves as Director at Large for the Controlled Release Society (CRS) since 2021.

Maria will talk about a rapid and cost-efficient strategy to analyze candidate compounds that inhibit exosome release or biogenesis using breast cancer cell line models.  Further development of this approach could help create high-throughput screening methodologies to identify molecules and rationally-designed nanomedicines.

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Speaker: Dr Davide Danovi (Senior Lecturer at King's College London)

Davide Danovi is Director, Cellular Phenotyping at bit.bio and Senior lecturer at King's College London at the Centre for Stem Cells and Regenerative Medicine. Davide has several years of experience developing phenotyping platforms to characterise stem cell behaviour in both university and biotechnology companies. He holds an MD from University of Milan and a PhD in Molecular Oncology from the European Institute of Oncology. He is part of the FLIER (Future Leaders for Innovation Enterprise and Research) group of the Academy of Medical Sciences.

Davide will talk about human stem cells which hold substantial promise for health. Quantification of cellular behaviour is of great importance in order to quality control and capture this potential. Here, he will present recent work aimed at developing assays largely based on high content imaging to profile cell behaviour of human stem cells developed at King's College London. He will also touch work from his team in bit.bio, an innovative biotechnology company in Cambridge UK combining synthetic and stem cell biology to code cells for health, enabling a new generation of cell platforms and cell therapies.

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Speaker: Anna-Lena Gustavsson (Director of Chemical Biology Consortium Sweden / Scilifelab, Senior scientist Chemical Biology Karolinska Institutet)

Anna-Lena Gustavsson, Director Chemical Biology Consortium Sweden, Scilifelab and Senior scientist Chemical Biology Karolinska Institutet, will talk about project examples and lessons learned from more than 10 years of operation of the Chemical Biology Consortium Sweden (CBCS). Sweden, through CBCS, is a watching partner, with potential to become a future member of EU-OPENSCREEN. CBCS is a SciLifeLab national research infrastructure and a powerful and integrated platform for the discovery, development and utilization of small molecules and chemical tools for life science applications in Sweden. 

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Speaker: Dr Sheraz Gul (Head of Assay Development & Screening, Fraunhofer IME ScreeningPort, Hamburg)

Drug discovery research and development in oncology aims to identify medicines that can maximise patient survival. Once treatment is initiated in cancer patients, drug resistance can be a limiting factor to achieving a cure. This can be overcome by the combined administration of drugs with non-overlapping mechanisms of action (poly-chemotherapy). In order to achieve this, chemosensitivity assays are required. This webinar will discuss the following topics:

1. Overview of cell-based assay systems.
2. Adapting cell-based assay systems for chemosensitivity assays.
3. Case studies of chemosensitivity assays.

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Speaker: Ctibor Škuta (Cheminformatician, CZ-OPENSCREEN)

Chemical probes are indispensable tools in modern biology. These compounds are commonly used to study gene function, validate molecular targets, or dissect complex processes within cells and organisms. Probes’ main attributes reside in their potency, selectivity, and well-defined mechanism of action, yet identifying compounds that meet all the demands of an experimental design is not a trivial task.

This webinar aims to introduce the main sources/providers of chemical probes along with the criteria to assess their quality. It will also provide an overview of data platforms helpful during their selection process with live demonstrations employing the Probes & Drugs portal (https://www.probes-drugs.org/, developed at the Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic).

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The speakers will present the DNA-encoded libraries (DEL) to Identify Novel Chemical Matter for Undruggable Targets - Webinar, a web-based theoretical overview for researchers and students considering DEL as part of their research.

Speakers:

Jorge Amigo (Galician Public Foundation for Xenomic Medicine)

Angel Carracedo (Universidad de Santiago (USC); Director of the Galician Public Foundation of Genomic Medicine and Director of the Spanish National Genotyping Centre)

Eduardo Dominguez (BioFarma Research Group, University of Santiago de Compostela)

Mabel Lloza (BioFarma Research Group, University of Santiago de Compostela)

Beatriz Sobrino (Galician Public Foundation for Genomic Medicine)

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Šárka Šímová (IMG, Prague, Czech Republic), Francisca Vicente (Fundación MEDINA, Granada, Spain), Sheraz Gul (IME, Hamburg, Germany) and Jose Manuel Brea (USC, Santiago de Compstela, Spain) presented a web-based theoretical course for researchers and students considering HTS as part of their research.

Webinar program:

• Target identification and definition (hit, lead, drug target), assay development
• Compound collection (desired properties, compound libraries)
• Assay optimization, pilot screen and primary screen Hit selection and confirmation
• Data analysis (detection technologies and data normalization)

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