Speaker: Dr Davide Danovi (Senior Lecturer at King's College London)
Davide Danovi is Director, Cellular Phenotyping at bit.bio and Senior lecturer at King's College London at the Centre for Stem Cells and Regenerative Medicine. Davide has several years of experience developing phenotyping platforms to characterise stem cell behaviour in both university and biotechnology companies. He holds an MD from University of Milan and a PhD in Molecular Oncology from the European Institute of Oncology. He is part of the FLIER (Future Leaders for Innovation Enterprise and Research) group of the Academy of Medical Sciences.
Davide will talk about human stem cells which hold substantial promise for health. Quantification of cellular behaviour is of great importance in order to quality control and capture this potential. Here, he will present recent work aimed at developing assays largely based on high content imaging to profile cell behaviour of human stem cells developed at King's College London. He will also touch work from his team in bit.bio, an innovative biotechnology company in Cambridge UK combining synthetic and stem cell biology to code cells for health, enabling a new generation of cell platforms and cell therapies.
Anna-Lena Gustavsson, Director Chemical Biology Consortium Sweden, Scilifelab and Senior scientist Chemical Biology Karolinska Institutet, will talk about project examples and lessons learned from more than 10 years of operation of the Chemical Biology Consortium Sweden (CBCS). Sweden, through CBCS, is a watching partner, with potential to become a future member of EU-OPENSCREEN. CBCS is a SciLifeLab national research infrastructure and a powerful and integrated platform for the discovery, development and utilization of small molecules and chemical tools for life science applications in Sweden.
Speaker: Anna-Lena Gustavsson (Director of Chemical Biology Consortium Sweden / Scilifelab, Senior scientist Chemical Biology Karolinska Institutet)
Drug discovery research and development in oncology aims to identify medicines that can maximise patient survival. Once treatment is initiated in cancer patients, drug resistance can be a limiting factor to achieving a cure. This can be overcome by the combined administration of drugs with non-overlapping mechanisms of action (poly-chemotherapy). In order to achieve this, chemosensitivity assays are required. This webinar will discuss the following topics:
1. Overview of cell-based assay systems.
2. Adapting cell-based assay systems for chemosensitivity assays.
3. Case studies of chemosensitivity assays.
Speaker: Dr Sheraz Gul (Head of Assay Development & Screening, Fraunhofer IME ScreeningPort, Hamburg)
Chemical probes are indispensable tools in modern biology. These compounds are commonly used to study gene function, validate molecular targets, or dissect complex processes within cells and organisms. Probes’ main attributes reside in their potency, selectivity, and well-defined mechanism of action, yet identifying compounds that meet all the demands of an experimental design is not a trivial task.
This webinar aims to introduce the main sources/providers of chemical probes along with the criteria to assess their quality. It will also provide an overview of data platforms helpful during their selection process with live demonstrations employing the Probes & Drugs portal (https://www.probes-drugs.org/, developed at the Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic).
Speaker: Ctibor Škuta (Cheminformatician, CZ-OPENSCREEN)
The speakers will present the DNA-encoded libraries (DEL) to Identify Novel Chemical Matter for Undruggable Targets - Webinar, a web-based theoretical overview for researchers and students considering DEL as part of their research.
Jorge Amigo (Galician Public Foundation for Xenomic Medicine)
Angel Carracedo (Universidad de Santiago (USC); Director of the Galician Public Foundation of Genomic Medicine and Director of the Spanish National Genotyping Centre)
Eduardo Dominguez (BioFarma Research Group, University of Santiago de Compostela)
Mabel Lloza (BioFarma Research Group, University of Santiago de Compostela)
Beatriz Sobrino (Galician Public Foundation for Genomic Medicine)
Šárka Šímová (IMG, Prague, Czech Republic), Francisca Vicente (Fundación MEDINA, Granada, Spain), Sheraz Gul (IME, Hamburg, Germany) and Jose Manuel Brea (USC, Santiago de Compstela, Spain) presented a web-based theoretical course for researchers and students considering HTS as part of their research.