Drug discovery research and development in oncology aims to identify medicines that can maximise patient survival. Once treatment is initiated in cancer patients, drug resistance can be a limiting factor to achieving a cure. This can be overcome by the combined administration of drugs with non-overlapping mechanisms of action (poly-chemotherapy). In order to achieve this, chemosensitivity assays are required. This webinar will discuss the following topics:
1. Overview of cell-based assay systems.
2. Adapting cell-based assay systems for chemosensitivity assays.
3. Case studies of chemosensitivity assays.
Speaker: Dr Sheraz Gul (Head of Assay Development & Screening, Fraunhofer IME ScreeningPort, Hamburg)
Chemical probes are indispensable tools in modern biology. These compounds are commonly used to study gene function, validate molecular targets, or dissect complex processes within cells and organisms. Probes’ main attributes reside in their potency, selectivity, and well-defined mechanism of action, yet identifying compounds that meet all the demands of an experimental design is not a trivial task.
This webinar aims to introduce the main sources/providers of chemical probes along with the criteria to assess their quality. It will also provide an overview of data platforms helpful during their selection process with live demonstrations employing the Probes & Drugs portal (https://www.probes-drugs.org/, developed at the Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic).
Speaker: Ctibor Škuta (Cheminformatician, CZ-OPENSCREEN)
The speakers will present the DNA-encoded libraries (DEL) to Identify Novel Chemical Matter for Undruggable Targets - Webinar, a web-based theoretical overview for researchers and students considering DEL as part of their research.
Jorge Amigo (Galician Public Foundation for Xenomic Medicine)
Angel Carracedo (Universidad de Santiago (USC); Director of the Galician Public Foundation of Genomic Medicine and Director of the Spanish National Genotyping Centre)
Eduardo Dominguez (BioFarma Research Group, University of Santiago de Compostela)
Mabel Lloza (BioFarma Research Group, University of Santiago de Compostela)
Beatriz Sobrino (Galician Public Foundation for Genomic Medicine)
Šárka Šímová (IMG, Prague, Czech Republic), Francisca Vicente (Fundación MEDINA, Granada, Spain), Sheraz Gul (IME, Hamburg, Germany) and Jose Manuel Brea (USC, Santiago de Compstela, Spain) presented a web-based theoretical course for researchers and students considering HTS as part of their research.