Translocation Transfer


Virtual Talk on: Rational design of balanced dual-targeting antibacterial compounds with limited resistance

Speaker: Prof. Lucija Peterlin Mašič, University of Ljubljana

Date: Tues, Oct 6, 2020 14:00-15:00 CET

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Abstract: Antibiotics that inhibit multiple bacterial targets offer a promising therapeutic strategy against resistance evolution, but developing such antibiotics is challenging. Here we demonstrate that a rational design of balanced multitargeting antibiotics is feasible by using a medicinal chemistry workflow. The resultant lead compounds belonging to a novel chemical class, almost equipotently inhibit bacterial DNA gyrase and topoisomerase IV complexes and interact with multiple evolutionary conserved amino acids in the ATP-binding pockets of their target proteins. Compounds are excellently potent against a broad range of gram-positive bacteria.

Events and Participations

  • Translocation Transfer Meeting, June 27th 5pm - July 3rd, 2020, Bremen, Germany 
  • Summer School June 2020, Bremen, Germany
  • World One Health Congress, June 14-18th, 2020, Edinborough, Scotland