Projects

Translocation Transfer

Aigars Jirgensons

Affiliation:

Latvian Institute of Organic Synthesis
Aizkraukles 21
Riga
LV-1006
Latvia

Contact:

Phone: +371 67014948
Email: aigars@osi.lv 
Webpage: www.osi.lv

Current Position:

Scientific director and group leader at Latvian Institute of Organic Synthesis; Professor at Riga Technical University

Keywords:

Anti-bacterial drug discovery, medicinal chemistry, fragment based lead discovery

Expertise:

Discovery of antibacterial drugs acting as inhibitors of aaRS enzymes, PLP dependent enzymes, lipoic acid biosynthesis enzymes, and efflux pump blockers and discovery of anti-malarial drugs acting as Plm inhibitors. Drug discovery projects are performed in collaboration with biophysical chemistry, bioanalytical and pharmacology groups at LIOS and other research centres. Our group provides synthetic optimization of hits originating from HTS, VS, FBLD and rational design as well as performs synthetic lead-to-CD optimization and scale-up studies.

Role in the network:

Medicinal, synthetic and analytical chemistry support for antibiotic drug discovery

References:

  • N-LeucinylBenzenesulfonamides as Structurally Simplified Leucyl-tRNASynthetase Inhibitors. Charlton et.al.ACS Med. Chem. 2018, 9, 84.
  • Recent patented antibacterial lead series: MX2017010357, WO2018065611