Projects

Translocation Transfer

Françoise Van Bambeke

Affiliation:

Université catholique de Louvain
Brussels
Belgium

Contact:

Phone : +32 2 764 73 78
Email : francoise.vanbambeke@uclouvain.be
Website:

Key words:

efflux pumps, pharmacokinetics/pharmacodynamics, biofilms/intracellular infection

Expertise:

Role of efflux in antibiotic intrinsic or acquired resistance; testing inhibitors of efflux including in biofilms/intracellular infections. Using collections of clinical isolates, we study the relationship between antibiotic resistance and expression of efflux pumps as well as the impact of natural mutations in genes encoding efflux pumps for recognition of antibiotics or for bacterial physiopathology. We also evaluate the interest of combining inhibitors of efflux with antibiotics, in particular in models of persistent infections like biofilms or intracellular survival.

Role in the network:

Elucidation of how active efflux contributes to modulate antibiotic pharmacokinetics and pharmacodynamics and define molecular determinants for antibiotic recognition by these transporters.

References:

  • Chalhoub H, Pletzer D, Weingart H, Braun Y, Tunney MM, Elborn JS, Rodriguez-Villalobos H, Plésiat P, Kahl BC, Denis O, Winterhalter M, Tulkens PM, Van Bambeke F. Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic. Scientific Reports (2017) 7:40208 (14 printedpages)
  • Buyck JM, Tulkens PM, Van Bambeke F. Activity of antibiotic combinations towards resistant strains of Pseudomonas aeruginosa in a model of infected THP-1 monocytes. Antimicrobial Agents and Chemotherapy (2015) 59:258-268