Translocation Transfer

Haim Barr

Affiliation:

The Weizmann Institute of Science

Contact:

Email: haim.barr@weizmann.ac.il
Phone: +972 8934 4379
Website: http://www.weizmann.ac.il/Staff_Scientists/haim-michael-barr

Key words:

High Throughput Screening, Drug Discovery Expertise: assay development, automation

Expertise:

The G-INCPM is a national technology center for advanced methodology and analytics. Dedicated platforms for genomics (sequencing), proteomics (targeted and profiling), bioinformatics (sequencing data and software development), drug discovery (small molecule screening, medicinal chemistry, cheminformatics) are integrated under one roof. The national nodes of Elixir (bioinformatics) and EU-Open screen (drug discovery) are located in G-INCPM.

Role in the network:

Small molecule discovery of chemical probes for novel biology by providing platforms for compound screening and hit triage with industry-level medicinal chemistry.

References:

• Plotnikov et al 2017 A multiplexed screening method for pluripotency. Stem Cell Res. 2017 Aug;23:158-162. doi: 10.1016/j.scr.2017.07.014.
• Ashkenazi et al 2017 Effective cell-free drug screening protocol for protein-protein interactions Anal Biochem. 2017 Sep 1;532:53-59. doi: 10.1016/j.ab.2017.05.030.
• Shraga et al 2019 Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.Cell Chem Biol. 2019 Jan 17;26(1):98-108.e5. doi: 10.1016/j.chembiol.2018.10.011