University of Oklahoma
Phone: +1 510 367 7731
Antibiotic resistance, efflux pumps and their inhibitors, transport mechanisms
biochemistry, microbiology, molecular transport The Center for Antibiotic Discovery and Resistance is a multidisciplinary research initiative by experts in microbiology, mechanistic biochemistry, experimental and computational biophysics and medicinal chemistry. The investigators are from the University of Oklahoma (Helen Zgurskaya, Valentin Rybenkov, AdamDuerfeldt), St Louis University (John Walker), Georgia Institute of Technology (JC Gumbart), University of Cagliari (Paolo Ruggerone), Memorial Sloan Kettering Cancer Center (Derek Tan), Los Alamos National Laboratory (Gnanakaran) and Oak Ridge National Laboratory (Jeremy Smith and Jerry Parks).
Support the discovery of fundamental principles that govern permeation of antibiotics into bacterial cells and to utilize them for the development of novel small molecule therapeutics effective against antibiotic resistant Gram-negative bacteria.