Projects

Translocation Transfer

Nevine S Fam

Affiliation:

Microbiology Dept. Theodor Bilharz Research Institute Affiliated to Ministry of Scientific research and Technology Cairo Egypt

Current Position:

Professor and Head of Microbiology Department

Contact:

Phone: 002 01005655520
Email: nevinefam@yahoo.com

Key words:

Antibiotic resistance, CRE, CRAb, Biofilm , Natural products, Synergism

Expertise:

Our work focuses on understanding antimicrobial resistance particularly in Gram negative bacteria including Enterobacteriaceae and Acinetobacter baumanii in clinical infections and colonized carriers. We investigate the antibacterial and antibiobilm activity of natural products such essential oils (Cinnameldehyde) against MDR strains of Acinetobacter using microbiological and scanning electron microscopy (SEM) approaches. Our studies into synergistic effects of new antibiotics such as (Doripenem) with older ones, (Colistin) are aimed at rescuing the use of older antimicrobials and providing additional therapeutic options to patients. In association with collaborators from Cairo University Medical School and Univ of Cologne we have analysed by WGS possible mechanism of colistin resistance in A. baumanii clinical isolates.

Role in the network:

Studies of antibiotic synergism as a route to improving overall efficacy

References:

  • Sara Mohamed, Dalia Salem, Magda Azmy, Nevine S Fam (2018) Antibacterial and antibiofilm activity of cinnameldehyde against carbapenem –resistant Acinetobacter baumannii in Egypt: in vitro study; J Applied Pharmaceutical Science 8(11):151-156 doi:10.7324/JAPS2018.81121
  • Nevine Fam Doaa Gamal, Magda Azmy, Reham wasfyet al (2017) Antimicrobial Efficacy of Doripenem Colistin combination on carbapenem –resistant Acinetobacter baumannii isolates by agar dilution and ultrastructural methods ; Egypt J Med Microbiol 26(1):1-7
  • Nevine Fam, Defasque, F Bert, V leflon-Gibout, A. El-Ray , M. El Ghanam, M.E. Atia, M. Omar, D.G. Desouki, VallaD. M-H. Nico;as-Chamione (2014) Faecal carriage of extended –spectrum β-lactamase (ESBL)-producing Enterobacteria in liver disease patients from two hospitals in Egypt and in France: a comparative epidemiologic study Epidem and infection
  • Nevine Fam , Leflon-Guibout V, Fouad S, Aboul-Fadl L, Marcon E, Desouky D, El- Defrawy I, Abou- Aitta A, Klena J , and Nicolas- Chanoine M-H (2010) :"High prevalence of CTX-M-15-producing Escherichia coli clinical isolates in Cairo (Egypt), including group A isolates of clonal complex ST10 and group B2 isolates of clones ST131, ST73 and ST405 in both community and hospital settings Micob Drug Resist Vol 17:67-73