Services

EU-OPENSCREEN's Compound Collections

EU-OPENSCREEN’s compound collections, enable researchers to study biological targets in Europe’s only open-access chemical biology infrastructure. Our main library, the European Chemical Biology Library (ECBL), is a curated collection of approximately 100,000 diverse compounds showcasing. These compounds have been designed by five leading academic computational chemistry groups from our partner sites.

We are committed to further enhancing this collection with innovative contributions from European chemists.

Our compound libraries are readily available for high-throughput screening (HTS) assays at EU-OPENSCREEN screening partner sites. Each compound undergoes comprehensive characterisation, including non-target-specific bioprofiling assays to evaluate physicochemical properties, antimicrobial activity, and potential cytotoxicity in cellular models.

 

Overview of EU-OPENSCREEN's Compound Collections

Sub-library (library)CountDescription
European Chemical Biology Library

98,560

Large diversity library selected by EU-OPENSCREEN sites

Please note the replenishment fees below when screening this library.

Representative diverse set (ECBL)

2,464

A representative subset of the diversity library

Bioactives

2,464

Custom bioactives library with emphasis on wide target coverage

Nuisance88

A representative set of nuisance compounds in biological screening

Pilot library5,016

Combination of the (i) representative diverse set, (ii) bioactives and (iii) nuisance libraries

Fragments (EFSL)1,056

Fragment library selected by EU-OPENSCREEN.
Read the paper: "Design, quality and validation of the EU-OPENSCREEN fragment library poised to high-throughput screening collection sites."

Mini 88 fragments (EFSL)88

A representative subset of the fragments library

Academic compounds (EACL)5,280

Compounds submitted to EU-OPENSCREEN by academic institutions

Total

107,414

 

Click here to download the library SDF, csv, xlsx, or json files in the ECBD

Costs for usage of the ECBL full library

If you would like to screen our European Chemical Biology Library (ECBL), a compound replenishment fee applies:

  • 15,000€ for users from EU-OPENSCREEN member countries (see member countries here)
  • 30,000€ for users from observer countries (see observer countries here).
  • 40,000€ for users from other countries
  • 42,000€ for industry users

Please note that all prices are reported as net prices.