With EU-OPENSCREEN´s unique compound collections you can explore the chemical space and target biology with Europe´s only open-access chemical biology infrastructure. Our main library, the European Chemical Biology Library (ECBL), consists of about 100.000 compounds with unbiased chemical diversity, designed by five academic computational chemistry groups, to which we will add over the next years a growing number of proprietary compounds collected from European chemists.
The compound collections can be used in high-throughput screening assays at any of our EU-OPENSCREEN screening partner sites.
All compounds in our libraries will be characterised in a panel of non-target specific bioprofiling assays (read more here), covering physicochemical and antimicrobial properties as well as potential cellular cytotoxicity.
Our pilot screening library consists of about 5.000 compounds. Half of these compounds represent our large European Chemical Biology Library (ECBL) of 100.000 commercial compounds while the other half is made up of about 2.500 bioactive compounds. EU-OPENSCREEN has recently purchased this unique library which was designed by Ctibor Skuta/ Petr Bartunek from our partner site IMG in Prague. A strong emphasis was put on the selection of molecules with high target selectivity.
The 2464 compounds are active against 1039 different targets, contain 654 approved drugs and 368 highly selective probes. A graphical overview about target and pathway coverage is shown below and was generated using the Probes & Drugs portal (www.probes-drugs.org). The bioactive library is provided in seven compound mother plates in 384-well format and is now available to research projects in collaboration with one of our partner sites.
Details on our bioactive compounds can be found here (pleae copy the link into your browser):