Services

EU-OPENSCREEN´s Compound Collections

With EU-OPENSCREEN´s unique compound collections you can explore the chemical space and target biology with Europe´s only open-access chemical biology infrastructure. Our main library, the European Chemical Biology Library (ECBL), consists of about 100.000 compounds with unbiased chemical diversity, designed by five academic computational chemistry groups, to which we will add over the next years a growing number of proprietary compounds collected from European chemists.

The compound collections can be used in high-throughput screening assays at any of our EU-OPENSCREEN screening partner sites.

All compounds in our libraries will be characterised in a panel of non-target specific bioprofiling assays (read more here), covering physicochemical and antimicrobial properties as well as potential cellular cytotoxicity.
    

Libraries available at EU-OPENSCREEN ERIC

European Chemical Biology Library (ECBL)

Diversity Library


  • 96.096 structurally highly diverse compounds
  • Average MW=350 g/mol
  • 0.0005 % of PAINS
Further informationDownload SD file

European Chemical Biology Library (ECBL)

Pilot Library with 2464 bioactive compounds


  • 2.464 bioactives: active against 1039 different targets, contain 654 approved drugs and 368 highly selective probes
  • 2.464 representative compounds of the diversity library
  • 88 assay interference compounds in 4 dilutions
Further informationDownload SD-File

European Academic Compound Library (EACL)

Novel donated compounds from chemists worldwide


  • In progress - built up since 2020, first working edition in 2022
  • Target is 40.000 compounds
  • Regulated and confidential access (e.g. MTA)
  • IP stays with the chemist
  • Embargo period up to 3 years
Further informationSubmission process and benefits

Fragment Library (FBLD)

Set of low MW and ultra-low MW fragments


  • 968 fragments with HAC > 8 in DMSO-d6
  • 88 so called “minifrags” with HAC < 8 in DMSO-d6 (O’Reilly M. et al., Drug Discov. Today 2019, 24, 1081)
  • Derived from the fragment space of the ECBL
  • Collaboration with INSTRUCT/ iNEXT-Discovery sites
Further informationDownload SD-File