Services

Medicinal Chemistry

Primary screening studies initially generate a list of compounds with the required biological activities (‘Hits’). These Hits rarely fulfil all the criteria for a quality “tool” compound as they typically show only a moderate affinity for the target and restricted selectivity.

To become a useful tool compound, the chemical properties of the initial Hits must therefore be iteratively improved by suitable structural modification. The post-screening Hit-to-tool optimisation process is carried out by accredited chemistry partner sites in EU-OPENSCREEN ERIC Member countries and is organised as a research collaboration between the assay provider and the respective chemistry site.

EU-OPENSCREEN Chemistry Partner Sites:

 CZ:

  • Masaryk University, Faculty of Science, Department of Chemistry, Dr. Kamil Paruch

DE:

  • Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Chemical Biology – Medicinal Chemistry group, Dr. Marc Nazaré

LV: 

  • Latvijas Organiskās sintēzes institūts, Riga, Latvia, Prof. Aigars Jirgensons, Dr. Osvalds Pugovics