Medicinal Chemistry

Primary screening studies initially generate a list of compounds with the required biological activities (‘Hits’). These Hits rarely fulfil all the criteria for a quality “tool” compound as they typically show only a moderate affinity for the target and restricted selectivity.

To become a useful tool compound, the chemical properties of the initial Hits must therefore be iteratively improved by suitable structural modification. The post-screening Hit-to-tool optimisation process is carried out by accredited chemistry partner sites in EU-OPENSCREEN ERIC Member countries and is organised as a research collaboration between the assay provider and the respective chemistry site.


EU-OPENSCREEN chemistry partner sites:



  • Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Chemical Biology – Medicinal Chemistry group, Dr. Marc Nazaré:
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  • Centro de Investigaciones Biologicas-CSIC, Translational Medicinal and Biological Chemistry Laboratory, Prof. Ana Martinez:

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  • Latvijas Organiskās sintēzes institūts, Riga, Latvia, Prof. Aigars Jirgensons, Dr. Osvalds Pugovics:
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  • Institute of Biochemistry and Biophysics (IBB), Polish Academy of Sciences, Prof. Dr. Piotr Zielenkiewicz:
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