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Medicinal Chemistry

Primary screening studies initially generate a list of compounds with the required biological activities (‘Hits’). These Hits rarely fulfil all the criteria for a quality “tool” compound as they typically show only a moderate affinity for the target and restricted selectivity.

To become a useful tool compound, the chemical properties of the initial Hits must therefore be iteratively improved by suitable structural modification. The post-screening Hit-to-tool optimisation process is carried out by accredited chemistry partner sites in EU-OPENSCREEN ERIC Member countries and is organised as a research collaboration between the assay provider and the respective chemistry site.

  

 

Medicinal chemistry partner sites

CZECH REPUBLIC


Masaryk University (MU) – Laboratory of Organic Synthesis and Medicinal Chemistry

Dr. Kamil Paruch

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Germany


Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) – Medicinal Chemistry

Dr. Marc Nazaré

Information PDF​​​​​​​

DENMARK


Technical University of Denmark (DTU) – Chemistry

Prof. Mads H. Clausen

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SPAIN


Center for Biological Research Margarita Salas (CSIC)

Prof. Dr. Ana Martínez

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LATVIA


Latvian Institute of Organic Synthesis (OSI)

Dr. Osvalds Pugovičs

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POLAND


Institute of Biochemistry and Biophysics (IBB PAS)

Prof. Dr. Piotr Zielenkiewicz

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