Services

Screening

An EU-OPENSCREEN screening site will take the robust, miniaturised assay together with established orthogonal and counter screens through the high throughput screening process, followed by confirmatory (dose response) and counter screening (identical assay without the target or with non-functional target), until a final list of confirmed hit compounds is established.

 

  

This process includes the following services:

  • HTS (of the entire EU-OPENSCREEN chemical collection)
  • In silico profiling, including basic chemoinformatic analysis and identification of frequent hitters and other potential false positives
  • Hit selection
  • Confirmatory screening, including orthogonal assay and IC/EC50 determination
  • Basic counter screening
  • Basic SAR based on screening data
  • QC of confirmed hits for a biochemical screen, the hit confirmation process includes testing for activity in a cell-based model.
  • Fragment based library screening
  • Virtual screening

 

EU-OPENSCREEN  Screening Partnersites:

CZ:

  • Palacký University Olomouc, Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine (IMTM), Dr. Marian Hajduch, Dr. Petr Dzubak
  • Institute of Molecular Genetics AS CR, v. v. i. (IMG), Dr. Petr Bartůněk

DE:

  • Leibniz Forschungsinstitut für Molekulare Pharmakologie (FMP)/MDC Berlin, Chemical Biology – Screening Unit, Dr. Jens Peter von Kries
  • Helmholtz-Zentrum für Infektionsforschung GmbH (HZI), Department of Chemical Biology (CBIO), Prof. Mark Brönstrup
  • Fraunhofer Institute for Molecular Biology and Applied Ecology IME- Department ScreeningPort, Dr. Bernhard Ellinger, Dr. Björn Windshügel, Dr. Sheraz Gul

ES:

  • FUNDACION MEDINA, Screening and target validation, Microbiology and Chemistry, Dr. Olga Genilloud 
  • Prince Felipe Research Center (CIPF), Advanced Therapies Program, Screening Platform, Dr. María J. Vicent
  • University of Santiago de Compostela, BioFarma Research Group, Prof. Mabel Loza

FI:

  • University of Helsinki, Faculty of Pharmacy, Division of Pharmaceutical Biosciences, Prof. Arto Urtti
  • Institute for Molecular Medicine Finland (FIMM), High Throughput Biomedicine (HTB) unit, Dr. Jani Saarela

NO:

  • University of Bergen, Department of Biomedicine, Faculty of Medicine and Dentistry, Prof. Aurora Martinez
  • University of Oslo, Faculty of Medicine, Biotechnology Centre of Oslo (BiO) and Centre for Molecular Medicine (NCMM), Prof. Kjetil Taskén
  • Arctic University of Norway, Faculty of Biosciences, Economics and Fisheries, Prof. Jeanette H. Andersen
  • SINTEF Materials and Chemistry, Dr. ing. Geir Klinkenberg

PL:

  • Institute of Medical Biology, Polish Academy of Sciences (IMB PAS), Screening laboratory for anti-viral and anti-bacterial compounds, Prof. Dr. Zbigniew J. Leśnikowski
  • Institute of Bioorganic Chemistry (IBCH), Polish Academy of Science, Dr. Radosław Pilarski
  • Institute of Biochemistry and Biophysics (IBB), Polish Academy of Sciences, Prof. Dr. Piotr Zielenkiewicz