The provision of highly qualified training is one of EU-OPENSCREEN´s core activities. Examples of relevant training topics are assay development, assay technologies, instrumentation and automation, compound management, and informatics.
In order to optimise collaboration and knowledge transfer, the continuos training of our platform staff through staff-exchanges and courses is a major focus. In addition, we are also providing training packages dedicated to Master and PhD students, postdoctoral scientists and independent principal investigators to foster the next generation of European researchers and to ensure the optimal use of the EU-OPENSCREEN infrastructure.
Speaker: Mads Hartvig Clausen, Professor of Chemistry, Technical University of Denmark (DTU) and Director of the DK-OPENSCREEN
Date: June 28, 2022 10:00 AM CEST
Free registration: https://us06web.zoom.us/webinar/register/WN_v0K6toVdQIuj6voCmDkYGA
Mads and his team are involved in the design, synthesis and screening of fragment libraries, as well as hit-to-lead medicinal chemistry. They are interesting in a range of protein target and more recently also RNA targets. Thus, new efforts are focused on the synthetic expansion of our fragment library to include molecules directed towards RNA targets, based on their established screening platform for 19F-NMR fragment screening with hit validation by 1H-NMR.
Speaker: Harald Schwalbe, Director Instruct ERIC
Date: May 31st at 10:00 CEST
Free registration: https://us06web.zoom.us/webinar/register/WN_RPMHyvosTQKFPdoskpWWWg
Integrated structural biology and medicinal chemistry are research with large mutual interest, substantial synergies, and need for coordination. At the same time, global challenges require coordinated research approaches on national and international level. European Research Infrastructure Consortia (ERICs) aim at identifying these mutuals interests and required coordination. The new Director of Instruct-ERIC, Harald Schwalbe, will discuss the potentials for collaborations on the example of: Coordinated research towards the development of anti-viral reactive compounds against SARS-CoV-2.
Speaker: María J. Vicent , CIPF Principe Felipe Research Center, Valencia
Date: April 26th 2022 at 10 AM CEST
Free registration: https://t.co/1XCEGt2g6T
María J. Vincent is responsible for the Screening Platform at CIPF, Valencia, one of the Specialist Screening Sites of EU-OPENSCREEN, where she coordinates the Advanced Therapies Program. She is part of the Strategic Committee of the Valencian Agency of Innovation (AVI) and serves as Director at Large for the Controlled Release Society (CRS) since 2021.
Maria will talk about a rapid and cost-efficient strategy to analyze candidate compounds that inhibit exosome release or biogenesis using breast cancer cell line models. Further development of this approach could help create high-throughput screening methodologies to identify molecules and rationally-designed nanomedicines.
Our partner site the Institute of Molecular Genetics is offering an on site training course on compound logistics in Prague, Czech Republic. The course is intended mainly for staff in charge of compound collection management and mainly for staff from EU-OPENSCREEN and prospective EU-OPENSCREEN partner sites
Prague, March 17-18, 2022.
Registration deadline: February 20, 2022
For registration please contact: Sarka Simova: firstname.lastname@example.org
Speaker: Dr Davide Danovi (Senior Lecturer at King's College London) https://www.kcl.ac.uk/people/davide-danovi
Date: March 29, 2022 10:00 AM CEST
Free registration https://us06web.zoom.us/webinar/register/WN_WGhfBetFQ_u-t2sbWi4yUg
Davide Danovi is Director, Cellular Phenotyping at bit.bio and Senior lecturer at King's College London at the Centre for Stem Cells and Regenerative Medicine. Davide has several years of experience developing phenotyping platforms to characterise stem cell behaviour in both university and biotechnology companies. He holds an MD from University of Milan and a PhD in Molecular Oncology from the European Institute of Oncology. He is part of the FLIER (Future Leaders for Innovation Enterprise and Research) group of the Academy of Medical Sciences.
Davide will talk about human stem cells which hold substantial promise for health. Quantification of cellular behaviour is of great importance in order to quality control and capture this potential. Here, he will present recent work aimed at developing assays largely based on high content imaging to profile cell behaviour of human stem cells developed at King's College London. He will also touch work from his team in bit.bio, an innovative biotechnology company in Cambridge UK combining synthetic and stem cell biology to code cells for health, enabling a new generation of cell platforms and cell therapies.
Anna-Lena Gustavsson, Director Chemical Biology Consortium Sweden, Scilifelab and Senior scientist Chemical Biology Karolinska Institutet, will talk about project examples and lessons learned from more than 10 years of operation of the Chemical Biology Consortium Sweden (CBCS). Sweden, through CBCS, is a watching partner, with potential to become a future member of EU-OPENSCREEN. CBCS is a SciLifeLab national research infrastructure and a powerful and integrated platform for the discovery, development and utilization of small molecules and chemical tools for life science applications in Sweden.
Are you looking for an open access compound library to perform high throughput screening (HTS)?
If your drug discovery project is at a stage in which you need to identify hits and optimize them, then you will be searching for the optimal compound libraries and HTS platforms. In this SPARK Europe Webinar our former Interim Lab Automation Manager, Dr. Edgar Specker, a medicinal chemist (Bayer, Zedira , Jerini ) with over 10 years of experience as compound library manager will present and explain the compound libraries and the screening services of EU OPENSCREEN. Do not miss this opportunity to learn more on our service offer. Free registration is open until Feb 1st, 2022. More information and the registration link can be found here.
This first edition of our EU-OPENSCREEN training school in autumn 2021 will present various aspects of chemical biology.
Starting with a general introduction to the field, we will continue by exploring more specific subjects such as
New services of EU-OPENSCREEN ERIC such as fragment screening and chemoproteomics will also be presented. Additionally, our speakers will introduce you to the EU-OPENSCREEN ERIC European Chemical Biology Database (ECBD), compound libraries and specific instruments which are used during compound management and screening campaigns.
For more information, registration and a detailed schedule,
please click here
This autumn school receives funding from the European Union´s Horizon 2020 research and innovation programme under grant agreement No 823893 (EU-OPENSCREEN-DRIVE).
Sheraz Gul, the speaker of this webinar, has gained extensive expertise in assay development and screening whilst working in academia, the pharmaceutical industry (GSK) and currently at Fraunhofer IME Screeningport in Hamburg. He has coordinated work packages in assay development, screening and Hit-to-Lead studies for many projects. He has co-authored >60 peer-reviewed papers, the Enzyme Assays: Essential Data handbook and organised 46 global assay development, screening and drug discovery workshops and trained more than 880 scientists.
Drug discovery research and development in oncology aims to identify medicines that can maximise patient survival. Once treatment is initiated in cancer patients, drug resistance can be a limiting factor to achieving a cure. This can be overcome by the combined administration of drugs with non-overlapping mechanisms of action (poly-chemotherapy). In order to achieve this, chemosensitivity assays are required. This webinar will discuss the following topics:
1. Overview of cell-based assay systems.
2. Adapting cell-based assay systems for chemosensitivity assays.
3. Case studies of chemosensitivity assays.
Download programme here.
How to use these powerful tools for the exploration of bioactive compound space? How to select the right set of tool compounds and controls for HTS experimental design?
Chemical probes are indispensable tools in modern biology. These compounds are commonly used to study gene function, validate molecular targets, or dissect complex processes within cells and organisms. Probes’ main attributes reside in their potency, selectivity, and well-defined mechanism of action, yet identifying compounds that meet all the demands of an experimental design is not a trivial task. Information on candidate probes are typically scattered over various sources, and gathering such information can be very time-consuming.
This webinar aims to introduce the main sources/providers of chemical probes along with the criteria to assess their quality. It will also provide an overview of data platforms helpful during their selection process with live demonstrations employing the Probes & Drugs portal (https://www.probes-drugs.org/, developed at the Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic).
Date: September 23rd, 2020. 15:00 - 16:15 CET
Speaker: Ctibor Škuta, Cheminformatician, CZ-OPENSCREEN
The speakers will present the DNA-encoded libraries (DEL) to Identify Novel Chemical Matter for Undruggable Targets - Webinar, a web-based theoretical overview for researchers and students considering DEL as part of their research.
Date: Monday, September 21st, 2020, 10:00-11:00 CET
Speakers (Brief CVs by alphabetic order):
Jorge AMIGO has a degree in Physics, a Master's degree in Bioinformatics and a PhD in Molecular Medicine. Since 2015, he has been the coordinator of the Bioinformatics Unit of the Galician Public Foundation for Xenomic Medicine, where he performs tasks both in support of routine diagnosis and research. He has over 10 years of experience in analyzing massive DNA sequencing data and over 5 years of experience in analyzing DEL libraries.
Angel CARRACEDO. Professor of Legal Medicine at the Universidad de Santiago (USC); Director of the Galician Public Foundation of Genomic Medicine and Director of the Spanish National Genotyping Centre. Committee member in numerous international societies for Genetics, Pharmacogenomics, Cancer and Forensic Medicine, numerous advisory committees of research centers and regulatory bodies. He has published more than 600 articles and is the most cited authors in the field of Forensic Medicine. He has received numerous prizes and has been nominated Doctor Honoris Causa by various universities in Europe and Latin America.
Eduardo DOMINGUEZ has a degree in Pharmacy and a PhD in Pharmacology. Since 2013, he has been the coordinator of the Biological Reagent Production Unit of the BioFarma Research Group, where he is involved in early drug discovery research projects. He has over 10 years of experience in developing assays and high-throughput screens by using a number of technologies, including DEL libraries.
Mabel LOZA. Professor of Pharmacology and head of BioFarma pharmacology research group at the University of Santiago de Compostela. Leader in the field of Early Drug Discovery at Spanish and European levels. Active participation in the development of 15 NCE that have reached clinical trials in the specific programs of R&D transfer in drug development of different pharmaceutical companies. Coordinator of the Drug Discovery Galician Network (2007-onwards) and the Drug Discovery Spanish Network of Excellence (REDEFAR) and the ES-OPENSCREEN Network connected to the ERIC EU- OPENSCREEN.
Beatriz SOBRINO has a degree in Biology, and a PhD in Molecular Medicine. Since 2009, she has been the coordinator of the DNA sequencing Unit of the Galician Public Foundation for Genomic Medicine, where she performs tasks both in support of routine genomic diagnosis and research. She has over 15 years of experience in massive DNA sequencing data and over 5 years of experience in sequencing experiments performed with DEL libraries.
The full programme can be downloaded here.
Šárka Šímová (IMG, Prague, Czech Republic), Francisca Vicente (Fundación MEDINA, Granada, Spain), Sheraz Gul (IME, Hamburg, Germany) and Jose Manuel Brea (USC, Santiago de Compstela, Spain) will present the Introduction to High-Throughput Screening - Webinar, a web-based theoretical course for researchers and students considering HTS as part of their research.
Date: Thursday, April 2, 2020, 15:00-16:15 CET
The course is intended mainly for staff in charge of compound collection management and mainly for staff from EU-OPENSCREEN and prospective EU-OPENSCREEN partner sites. The maximum capacity of the course is 10 attendees. The course will be organized every year during the DRIVE project (2020, 2021 and 2022).
As is it stated in the document, the final program can be customized depending on the specific interests of the individual attendees, covering and discussing the suggested topics more in depth. For more information and for registration please contact CZ-OPENSCREEN, Mrs. Sarka Simova.
EU-OPENSCREEN Director, Wolfgang Fecke, will give an online webinar together with Mathew Hall (NIH-NCATS) on "Quality in Screening", on November 19 from 15:00 to 16:00 CET. The webinar will focus on quality standards and assay guidelines in high-throughput screening as part of a new series of open access online courses and webinars on hot topics in Translational Medicine offered by EATRIS starting this fall.
For more information see here.