Services

Training Courses

The provision of highly qualified training is one of EU-OPENSCREEN´s core activities. Examples of relevant training topics are assay development, assay technologies, instrumentation and automation, compound management, and informatics.

In order to optimise collaboration and knowledge transfer, the continuos training of our platform staff through staff-exchanges and courses is a major focus. In addition, we are also providing training packages dedicated to Master and PhD students, postdoctoral scientists and independent principal investigators to foster the next generation of European researchers and to ensure the optimal use of the EU-OPENSCREEN infrastructure.

Webinar: Tool compound/Probe evaluation and selection September 2020

How to use these powerful tools for the exploration of bioactive compound space, how to select the right set of tool compounds and controls for HTS experimental design?

The detailed program will be announced.

Date: September 22rd, 2020. 15:00 - 16:15 CET

Location: Webex Dial-In (will be provided after registration) Registration: Šárka Šímová, send e-mail (registration will be open from August 24th, 2020)

This webinar is free to attend, but you need to register for a place beforehand. The webinar will be hosted on CISCO Webex

Webinar “DNA-encoded libraries to identify novel chemical matter for undruggable targets”

The Department of Pharmacology at the University of Santiago de Compostela (USC) is organising the webinar “DNA-encoded libraries to identify novel chemical matter for undruggable targets” in September 2020. The training webinar is open for everyone and will be focused on the use of DNA-encoded libraries to identify novel chemical matter by target-based screen. The protein models to be developed may include promising examples of unmet clinical needs from common, highly prevalent disorders affecting a significant number of patients, but with technologically/biologically challenging properties (e.g. protein-protein interactions, transcription factors, etc...). These assays are performed by affinity selection HTS format and then the decoding of DEL libraries is done by next generation sequencing (e.g. Ion Torrent, Illumina, Nanopore) and bioinformatic analysis with in house tools. After a series of affinity selection assays and screening data analysis of sequences and data transfer, a list of candidates are resynthesized off-DNA to be tested in further models for the evaluation of the biological activity and rank order the prioritized candidates which will be then ready to be used for further validation of biological activity in relevant disease and mechanism of action models.

For more info please contact Pepo Brea at USC here.

 

 

Previous Training Courses

Webinar "Introduction to High-Throughput Screening" - Thursday, April 2, 2020, 15:00-16:15 CET

Šárka Šímová (IMG, Prague, Czech Republic), Francisca Vicente (Fundación MEDINA, Granada, Spain), Sheraz Gul (IME, Hamburg, Germany) and Jose Manuel Brea (USC, Santiago de Compstela, Spain) will present the Introduction to High-Throughput Screening - Webinar, a web-based theoretical course for researchers and students considering HTS as part of their research.

Webinar program:

  • Target identification and definition (hit, lead, drug target), assay development
  • Compound collection (desired properties, compound libraries)
  • Assay optimization, pilot screen and primary screen Hit selection and confirmation
  • Data analysis (detection technologies and data normalization)

Date: Thursday, April 2, 2020, 15:00-16:15 CET Location:

Webex Dial-In (will be provided after registration)

Registration: Šárka Šímová (first come, first served)

This webinar is free to attend, but you need to register for a place beforehand. The webinar will be hosted on CISCO Webex.

Compound Logistics Course

Place: Institute of Molecular Genetics (IMG) CZ-OPENSCREEN Prague

Date: November 28, 2019 |  Registration deadline: October 31st, 2019

The course is intended mainly for staff in charge of compound collection management and mainly for staff from EU-OPENSCREEN and prospective EU-OPENSCREEN partner sites. The maximum capacity of the course is 10 attendees. The course will be organized every year during the DRIVE project (2020, 2021 and 2022).

Course program:
Compound_logistics_course_Prague_2019.pdf

As is it stated in the document, the final program can be customized depending on the specific interests of the individual attendees, covering and discussing the suggested topics more in depth. For more information and for registration please contact CZ-OPENSCREEN, Mrs. Sarka Simova.

Webinar: "Quality in Screening"

Lecturers: Matthew Hall (NIH/NCATS) and Wolfgang Fecke (EU-OPENSCREEN)

Online: November 19 from 15:00 to 16:00 CET

EU-OPENSCREEN Director, Wolfgang Fecke, will give an online webinar together with Mathew Hall (NIH-NCATS) on "Quality in Screening", on November 19 from 15:00 to 16:00 CET. The webinar will focus on quality standards and assay guidelines in high-throughput screening as part of a new series of open access online courses and webinars on hot topics in Translational Medicine offered by EATRIS starting this fall.

For more information see here.