Services

Training Courses

The provision of highly qualified training is one of EU-OPENSCREEN´s core activities. Examples of relevant training topics are assay development, assay technologies, instrumentation and automation, compound management, and informatics.

In order to optimise collaboration and knowledge transfer, the continuos training of our platform staff through staff-exchanges and courses is a major focus. In addition, we are also providing training packages dedicated to Master and PhD students, postdoctoral scientists and independent principal investigators to foster the next generation of European researchers and to ensure the optimal use of the EU-OPENSCREEN infrastructure.

 

    

Previous Training Courses

Webinar: Introduction to chemosensitive profiling - Novemver 26th, 2020,15:00-16:00 CET

Speaker: Dr Sheraz Gul, Head of Assay Development & Screening, Fraunhofer IME ScreeningPort, Hamburg

Sheraz Gul, the speaker of this webinar, has gained extensive expertise in assay development and screening whilst working in academia, the pharmaceutical industry (GSK) and currently at Fraunhofer IME Screeningport in Hamburg.  He has coordinated work packages in assay development, screening and Hit-to-Lead studies for many projects. He has co-authored >60 peer-reviewed papers, the Enzyme Assays: Essential Data handbook and organised 46 global assay development, screening and drug discovery workshops and trained more than 880 scientists.

Drug discovery research and development in oncology aims to identify medicines that can maximise patient survival. Once treatment is initiated in cancer patients, drug resistance can be a limiting factor to achieving a cure. This can be overcome by the combined administration of drugs with non-overlapping mechanisms of action (poly-chemotherapy). In order to achieve this, chemosensitivity assays are required. This webinar will discuss the following topics:

1. Overview of cell-based assay systems.
2. Adapting cell-based assay systems for chemosensitivity assays.
3. Case studies of chemosensitivity assays.

Download programme here.

 

Webinar "Tool compound/Probe evaluation and selection" - September 23rd, 2020

How to use these powerful tools for the exploration of bioactive compound space? How to select the right set of tool compounds and controls for HTS experimental design?

Chemical probes are indispensable tools in modern biology. These compounds are commonly used to study gene function, validate molecular targets, or dissect complex processes within cells and organisms. Probes’ main attributes reside in their potency, selectivity, and well-defined mechanism of action, yet identifying compounds that meet all the demands of an experimental design is not a trivial task. Information on candidate probes are typically scattered over various sources, and gathering such information can be very time-consuming.

This webinar aims to introduce the main sources/providers of chemical probes along with the criteria to assess their quality. It will also provide an overview of data platforms helpful during their selection process with live demonstrations employing the Probes & Drugs portal (https://www.probes-drugs.org/, developed at the Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic).

Date: September 23rd, 2020. 15:00 - 16:15 CET

Speaker: Ctibor Škuta, Cheminformatician, CZ-OPENSCREEN

    

Webinar “DNA-encoded libraries to identify novel chemical matter for undruggable targets”

The speakers will present the DNA-encoded libraries (DEL) to Identify Novel Chemical Matter for Undruggable Targets - Webinar, a web-based theoretical overview for researchers and students considering DEL as part of their research.

  • DEL technology is a game changing innovation in Drug Discovery to expand ligandability of targets.
  • With DEL, synthesis and screening of millions (even billions) of novel and highly diverse drug-like compounds is more efficient than conventional methods to identify new ligands with instant SAR information and to assess target ligandability applicable across disease areas and target classes. 
  • It is now a well-established technology in the pharmaceutical industry used by GSK, Roche, Novartis, Pfizer, AZ, Merck, … and other companies in connection with the academic developments. 
  • A number of DEL-originated compounds are currently in clinical stages and may potentially impact drug development pipelines.


Date: Monday, September 21st, 2020, 10:00-11:00 CET
 

Speakers (Brief CVs by alphabetic order):

Jorge AMIGO has a degree in Physics, a Master's degree in Bioinformatics and a PhD in Molecular Medicine. Since 2015, he has been the coordinator of the Bioinformatics Unit of the Galician Public Foundation for Xenomic Medicine, where he performs tasks both in support of routine diagnosis and research. He has over 10 years of experience in analyzing massive DNA sequencing data and over 5 years of experience in analyzing DEL libraries.

Angel CARRACEDO. Professor of Legal Medicine at the Universidad de Santiago (USC); Director of the Galician Public Foundation of Genomic Medicine and Director of the Spanish National Genotyping Centre. Committee member in numerous international societies for Genetics, Pharmacogenomics, Cancer and Forensic Medicine, numerous advisory committees of research centers and regulatory bodies. He has published more than 600 articles and is the most cited authors in the field of Forensic Medicine. He has received numerous prizes and has been nominated Doctor Honoris Causa by various universities in Europe and Latin America.

Eduardo DOMINGUEZ has a degree in Pharmacy and a PhD in Pharmacology. Since 2013, he has been the coordinator of the Biological Reagent Production Unit of the BioFarma Research Group, where he is involved in early drug discovery research projects. He has over 10 years of experience in developing assays and high-throughput screens by using a number of technologies, including DEL libraries.

Mabel LOZA. Professor of Pharmacology and head of BioFarma pharmacology research group at the University of Santiago de Compostela. Leader in the field of Early Drug Discovery at Spanish and European levels. Active participation in the development of 15 NCE that have reached clinical trials in the specific programs of R&D transfer in drug development of different pharmaceutical companies. Coordinator of the Drug Discovery Galician Network (2007-onwards) and the Drug Discovery Spanish Network of Excellence (REDEFAR) and the ES-OPENSCREEN Network connected to the ERIC EU- OPENSCREEN.

Beatriz SOBRINO has a degree in Biology, and a PhD in Molecular Medicine. Since 2009, she has been the coordinator of the DNA sequencing Unit of the Galician Public Foundation for Genomic Medicine, where she performs tasks both in support of routine genomic diagnosis and research. She has over 15 years of experience in massive DNA sequencing data and over 5 years of experience in sequencing experiments performed with DEL libraries.

The full programme can be downloaded here.

    

Webinar "Introduction to High-Throughput Screening" - Thursday, April 2, 2020, 15:00-16:15 CET

    
Šárka Šímová (IMG, Prague, Czech Republic), Francisca Vicente (Fundación MEDINA, Granada, Spain), Sheraz Gul (IME, Hamburg, Germany) and Jose Manuel Brea (USC, Santiago de Compstela, Spain) will present the Introduction to High-Throughput Screening - Webinar, a web-based theoretical course for researchers and students considering HTS as part of their research.
  

Webinar program:

  • Target identification and definition (hit, lead, drug target), assay development
  • Compound collection (desired properties, compound libraries)
  • Assay optimization, pilot screen and primary screen Hit selection and confirmation
  • Data analysis (detection technologies and data normalization)

Date: Thursday, April 2, 2020, 15:00-16:15 CET

Compound Logistics Course

Place: Institute of Molecular Genetics (IMG) CZ-OPENSCREEN Prague

Date: November 28, 2019 |  Registration deadline: October 31st, 2019

The course is intended mainly for staff in charge of compound collection management and mainly for staff from EU-OPENSCREEN and prospective EU-OPENSCREEN partner sites. The maximum capacity of the course is 10 attendees. The course will be organized every year during the DRIVE project (2020, 2021 and 2022).

Course program:
Compound_logistics_course_Prague_2019.pdf

As is it stated in the document, the final program can be customized depending on the specific interests of the individual attendees, covering and discussing the suggested topics more in depth. For more information and for registration please contact CZ-OPENSCREEN, Mrs. Sarka Simova.

Webinar: "Quality in Screening"

Lecturers: Matthew Hall (NIH/NCATS) and Wolfgang Fecke (EU-OPENSCREEN)

Online: November 19 from 15:00 to 16:00 CET

EU-OPENSCREEN Director, Wolfgang Fecke, will give an online webinar together with Mathew Hall (NIH-NCATS) on "Quality in Screening", on November 19 from 15:00 to 16:00 CET. The webinar will focus on quality standards and assay guidelines in high-throughput screening as part of a new series of open access online courses and webinars on hot topics in Translational Medicine offered by EATRIS starting this fall.

For more information see here.