Helmholtz-Zentrum für Infektionsforschung (HZI)
The HZI offers a fully automated system for screening campaigns under BSL2-conditions, which is suitable for either target-based assays or phenotypic assays using the coronavirus H229E. In addition the activity of identified hits from target-based screens against the whole virus SARS-Cov-2 can be validated in the BSL3 laboratory.
This laboratory is also fully equipped for screening campaigns, in a smaller scale, using a semi-automated system. Moreover, support can be offered for chemical optimisation of compounds and for evaluation of preclinical parameters, such as ADME-Tox and PK/PD properties.
Helmholtz-Zentrum für Infektionsforschung
COVID-19 Activity Profile
COVID-19 Activity Profile
The HZI offers a fully automated system for screening campaigns under BSL2-conditions, which is suitable for either target-based assays or phenotypic assays using the coronavirus H229E. In addition the activity of identified hits from target-based screens against the whole virus SARS-Cov-2 can be validated in the BSL3 laboratory.
This laboratory is also fully equipped for screening campaigns, in a smaller scale, using a semi-automated system. Moreover, support can be offered for chemical optimisation of compounds and for evaluation of preclinical parameters, such as ADME-Tox and PK/PD properties.
Helmholtz-Zentrum für Infektionsforschung (HZI)
Department of Chemical Biology (CBIO)
| COVID-19 Activity | Status |
|---|---|
| H2020-MSCA-ITN-2020: "TRAINAT" (antivirals from natural products) M. Brönstrup | Submitted |
| EU-project 'SCORE': Contribution to optimization of protease inhibitors K. Rox, M. Brönstrup | Accepted |
| IMI call (EUROCOVID together with EU OPENSCREEN) U. Bilitewski, M. Brönstrup | Submitted |
| Screening in house libraries for anti-SARS-CoV2-inhibitors in target-based and phenotypic viral assays U. Bilitewski, M. Brönstrup | Ongoing |