Schedule
Programme | ||
Thursday, 20 May 2010 | ||
07:30 | Bus Transfer from hotels | |
08:00 | Registration | |
08:40 | Opening | |
Session 1: Chemical Biology in Europe and beyond (J. Quintana & K. Tasken) | ||
08:45 | Keynote lecture NIH Molecular Libraries Program: Integrative Technologies Enabling Biology and Chemistry as a Public Resource for Translational Research | James Inglese (Bethesda, USA) |
09:30 | Academic screening, challenges and new opportunities | Phil Gribbon (Hamburg, Germany) |
10:00 | Approaches to Drug Discovery for Tropical Diseases | Ian Gilbert (Dundee, UK) |
10:30 | Chemical Biology of Protein-Protein Interactions: Challenges and Opportunities | Joe Lewis (Heidelberg, Germany) |
11:00 | Coffee break | |
Session 2: Chemical chaperones and Protein Aggregation (R. Frank & M. Hibert) | ||
11:30 | Keynote lecture Small molecule compounds: novel therapeutics for genetic diseases due to misfolding? | Peter M.T. Deen (Nijmegen, Netherlands) |
12:15 | Biased agonists pharmacochaperones of the V2 vasopressin receptor as potential therapeutic agents for nephrogenic diabetes insipidus | Christiane Mendre (Montpellier, France) |
12:45 | Two unrelated antiprion drugs isolated using a yeast-based assay are specific inhibitors of Ribosome-borne Protein Folding Activity (RPFA) | Marc Blondel (Brest, France) |
13:15 | Chemical Chaperones Modulate Protein Misfolding Pathways in Neurodegenerative Diseases | Erich Wanker (Berlin, Germany) |
13:45 | Lunch | |
Session 3: New Challenges and Avenues (T. Nielsen & O. Kallioniemi) | ||
14:45 | Keynote lecture Drugging the cancer genome: Chemical probes and drugs in the clinic | Paul Workman (London, UK) |
15:30 | Chemical probes for systems biology | Jordi Mestres (Barcelona, Spain) |
16:00 | How to turn a protein kinase ON and OFF using the same switch: High resolution complex structure and allosteric effects of low molecular weight activators on the protein kinase PDK1 (selected from abstracts) | Ricardo M. Biondi (Frankfurt, Germany) |
16:15 | A boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation (selected from abstracts) | Huib Ovaa (Amsterdam, Netherlands) |
16:30 | Prospects and Challenges in Open Source Drug Discovery: Strategies to Conquer the Valley of Death (selected from abstracts) | Rathnam Chaguturu (Kansas, USA) |
| 17:00: Poster and Czech beer session & BBQ | ||
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Friday, 21 May 2010 | ||
8:30 | Bus Transfer from hotels | |
Session 4 Protein modifications (G. Superti-Furga & A. Levitzki) | ||
09:00 | Keynote lecture The interplay between phosphorylation and ubiquitylation in regulating innate immunity | Sir Philip Cohen (Dundee, UK) |
09:45 | Molecular targets, mechanisms and opportunities for combination therapies of multi-targeted kinase inhibitors | Uwe Rix (Vienna, Austria) |
10:15 | Open Access Chemical Probes for Epigenetic Proteins | Tom Heightman (Oxford, UK) |
10:45 | EGFR receptor guided delivery of long chain dsRNA | Alex Levitzki (Jerusalem, Israel) |
11:15 | Coffee break | |
Session 5: New Challenges and Avenues (T. Nielsen, O. Kallioniemi) | ||
11:45 | Combinatorial Chemistry for the Chemical Biology of the GPCR's | Morten Meldal (Copenhagen, Denmark) |
12:15 | Chemical and Biological Diversity: New Approaches to Synthesising Bioactive Small Molecules | Adam Nelson (Leeds, UK) |
12:45 | Small molecules as inhibitors of Interleukin 8 expression (selected from abstracts) | Marc Reboll (Braunschweig, Germany) |
13:00 | Synthetic Mimicry of Protein Binding Sites for the Exploration and Modulation of Protein-Protein Interactions (selected from abstracts) | Jutta Eichler (Braunschweig, Germany) |
13:15 | Lunch | |
Session 6: Stem cell biology (P. Bartunek, K. Wennerberg ) | ||
14:15 | Keynote lecture Chemical Biology and Zebrafish | Leonard I. Zon (Boston, USA) |
15:00 | Targeting chromatin for transdifferentiation in the pancreas | Stefan Kubicek (Cambridge, USA) |
15:30 | Deconvoluting the role of Glycogen synthase kinase-3 in embryonic stem cellfate decisions using a chemical genetic approach | Melanie J. Welham (Bath, UK) |
16:00 | Slow cycling cells in pancreas adenocarcinoma as potential drug targets | Stefan Krauss (Oslo, Norway) |
16:30 | Coffee break | |
| 16:45: Poster session II - National Networks | ||
17:45 | Bus Transfer to hotels | |
19:20 | Meeting point - Charles Bridge Museum | |
19:30 | Welcome drink / Final remarks / Closing / Poster Awards | |
20:30 | Conference dinner - Boat Nepomuk | |