Schedule
July 2 Sunday
| 11.00– | Registration |
| 11.30–14.00 | EU‑OPENSCREEN Partner Site Workshop |
| 15.30–15.45 | Opening ceremony |
| 15.45–16.30 | Chair: Ronald Frank |
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PL‑1 Herbert Waldmann, Max Planck Institute of Molecular Physiology, Germany Chemotype‑Phenotype‑Target | |
| 16.30–17.00 |
Session 1: Screening technologies: assay design, development and hit validation Chair: Gergely Makara |
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KL‑1 Hans Bräuner‑Osborne, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark Screening technologies: assay design, development and hit validation | |
| 17.00–17.15 |
OL‑1 Mercedes Beyna, Biogen, USA Discovery of novel transcriptional regulation of NF‑kB signaling via phenotypic screening and chemoproteomics |
| 17.15–17.45 |
Session 2: Molecular targets and systems Chair: Attila Reményi |
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KL‑2 Patrick Aloy, Institute for Research in Biomedicine, Spain A network biology approach to novel therapeutic strategies | |
| 17.45–18.00 |
OL‑2 Veronika F. S. Pape, Hungarian Academy of Sciences, Institute of Enzymology, Hungary Putting the bite on metals – a ligand‑based approach to overcome multidrug resistance in cancer |
| 18.00–20.00 | Welcome reception |
July 3 Monday
| 9.00–9.45 |
Chair: Bahne Stechmann PL‑2 Stefan Knapp, Buchmann Institute for Molecular Life Sciences, Frankfurt am Main Systematic validation of new disease targets by chemical probes |
| 9.45–10.15 |
Session 3: Chemoinformatics Chair: György Ferenczy |
|
KL‑3 Didier Rognan, CNRS, France Structure‑based discovery of allosteric modulators of receptor tyrosine kinases | |
| 10.15–10.30 |
OL‑3 Albert A. Antolin, The Institute of Cancer Research, UK Target‑Probes Assessment Resource: Objective, Quantitative, Unbiased Assessment of Chemical Probes |
| 10.30–11.00 | Coffee break |
| 11.00–11.25 |
Session 4: Library design and chemical diversity Chair: György Dormán |
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KL‑4 Gergely Makara The evolution of library design from combichem to in‑silico organic chemistry | |
| 11.25–11.40 |
OL‑4 Yurii Moroz, Enamine Ltd, Ukraine Real Fragment‑Like Covalent Modifiers / Real Arrays – A Comprehensive Database Of Readily Synthesizable Molecules |
| 11.40–11.55 |
OL‑5 Andrea Trabocchi, University of Florence Diversity‑Oriented Synthesis of heterocyclic sp3‑rich molecular scaffolds through build/couple/pair of carbohydrate and amino acid derivatives |
| 11.55–12.25 |
Session 5: Manipulation of cellular states and combatting diseases Chair: Gergely Szakács |
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KL‑5 Hans Schöler, Max Planck Institute for Molecular Biomedicine, Germany Induction of Pluripotent and Multipotent Stem Cells | |
| 12.25–12.40 |
OL‑6 Maria J. Vicent, Centro Investigación Príncipe Felipe, Spain Tumor‑derived exosome release as novel target to identify effective anticancer combination therapies for metastatic processes |
| 12.40–14.15 | Lunch |
| 14.15–14.45 |
Session 6: Biocompatible labelling and imaging Chair: Péter Kele |
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KL‑6 Hans‑Achim Wagenknecht, Karlsruhe Institute of Technology, Germany Bioorthogonal labeling of nucleic acids for fluorescent imaging | |
| 15.15–15.30 |
OL‑7 Eszter Kozma, Hungarian Academy of Sciences, Research Centre for Natural Sciences, Hungary Intracellular superresolution microscopy enabled by bioorthogonal double‑fluorogenic silicorhodamine‑tetrazine probes |
| 15.30–16.00 | Coffee Break |
| 16.00–17.15 | Poster session |
| 17.15–19.00 | Leaving to dinner |
| 19.00– | Dinner |
July 4 Tuesday
| 9.00–9.45 |
Chair: Philip Gribbon PL‑3 John P. Overington, Medicines Discovery Catapult, UK Data Mining in Small Molecule Drug Discovery |
| 9.45–10.15 |
Session 7: Plant biotech and natural products Chair: Gábor Vasas |
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KL‑7 Anne Osbourn, John Innes Centre, Norwich, UK Harnessing plant metabolic diversity: from genomes to gram‑scale quantities of natural products and analogs | |
| 10.15–10.30 |
OL‑8 Francisca Vicente, Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Spain Application of Labcyte Echo® Liquid Handling to Microbial Natural Product Extracts and Pure Compounds from MEDINA Library in High‑Throughput Miniaturized Assays |
| 10.30–11.00 | Coffee break |
| 11.00–11.30 |
Session 8: Photochemical applications Chair: Gábor London |
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KL‑8 José Luis Mascareñas, Universidad de Santiago de Compostela, Spain Metal‑based tools in Chemical Biology | |
| 11.30–11.45 |
OL‑9 Lilia Reytman, Institute of Chemistry, The Hebrew University of Jerusalem, Israel Hydrolytically Stable Vanadium(V) Phenolato Antitumor Agents: The role of the ligand in the cytotoxic pathway |
| 11.45–12.05 |
Short talks (5' each) Chair: Katja Herzog |
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ST‑1 Frederic Friscourt, Institut Européen de Chimie et Biologie – University of Bordeaux, France A Turn‑On Bioorthogonal Probe for the Selective Visualization of Biomolecules in No‑Wash Conditions | |
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ST‑2 Csaba Hetényi, University of Pécs, Hungary Unraveling the histone code by fragment blind docking | |
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ST‑3 Attila Kormos, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary Double Quenched Fluorogenic Cyanines for bioorthogonal two‑point tagging | |
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ST‑4 Ctibor Skuta, Institute of Molecular Genetics of the ASCR, Czech Republic Probes & Drugs portal: interactive approach to Open Data exploration in chemical biology | |
| 12.05–13.05 | Partner Site Demonstrations |
| 13.05–13.20 | Closing ceremony |
| 13.20 | Lunch |