EU-OPENSCREEN's Compound Collections
Overview of EU-OPENSCREEN's Compound Collections Test
| Sublibrary (library) | Count | Description |
| Diversity (ECBL) | 98,560 | Large diversity library selected by EU-OPENSCREEN sites Please note the replenishment fees when screening this library (see details below) |
| Representative diverse set (ECBL) | 2,464 | A representative subset of the diversity library Download SD-File |
| Bioactives | 2,464 | Custom bioactives library with emphasis on wide target coverage |
| Nuisance | 88 | A representative set of nuisance compounds in biological screening |
| Pilot library | 5,016 | Combination of the (i) representative diverse set, (ii) bioactives and (iii) nuisance libraries |
| Fragments (EFSL) | 1,056 | Fragment library selected by EU-OPENSCREEN. Paper: "Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection sites." Download SD-File |
| Mini 88 fragments (EFSL) | 88 | A representative subset of the fragments library |
| Academic compounds (EACL) | 5,280 | Compounds submitted to EU-OPENSCREEN by academic institutions |
| Total | 107,414 |
Costs for usage of the ECBL full library
If you would like to screen our European Chemical Biology Library (ECBL), a compound replenishment fee applies:
- 15.000€ for users from EU-OPENSCREEN member countries (see member countries here)
- 30.000€ for users from observer countries (see observer countries here).
- 40.000€ for users from other countries
- 42.000€ for industry users
Please note that all prices are reported as net prices.
European Chemical Biology Library (ECBL)
Diversity Library
- 96,560 structurally highly diverse compounds
- Average MW=350 g/mol
European Chemical Biology Library (ECBL)
Pilot Library with 2464 bioactive compounds
- 2,464 bioactives: active against 1039 different targets, contain 654 approved drugs and 368 highly selective probes
- 2,464 representative compounds of the diversity library
- 88 assay interference compounds in 4 dilutions
European Academic Compound Library (EACL)
Novel submitted compounds from chemists worldwide
- In progress - built up since 2020, first working edition in 2022
- Target is 40,000 compounds
- Regulated and confidential access (e.g. MTA)
- IP stays with the chemist
- Embargo period up to 3 years
European Fragment Screening Library (EFSL)
Set of low MW and ultra-low MW fragments
- 968 fragments with HAC > 8 in DMSO-d6
- 88 so called “minifrags” with HAC < 8 in DMSO-d6 (O’Reilly M. et al., Drug Discov. Today 2019, 24, 1081)
- Derived from the fragment space of the ECBL
- Collaboration with INSTRUCT/ iNEXT-Discovery sites