EU-OPENSCREEN - AUTUMN TRAINING SCHOOL 2022

We are very happy to present the 2022 edition of our online AUTUMN TRAINING SCHOOL!

Target group: Everyone with an interest in science although young scientists are preferably welcomed for a great opportunity to meet distinguished speakers and discuss scientific, but also career questions, during the training school Q&A sessions.

Participation fee: free of charge

Registration deadline: November 8th 2022

This autumn school receives funding from the European Union´s Horizon 2020 research and innovation programme under grant agreement No 823893 (EU-OPENSCREEN-DRIVE).

Topics

This second edition of our training school will present various aspects of chemical biology

Starting with a general introduction to the field, we will continue by exploring more specific subjects such as

  • High Throughput Screening (HTS)
  • Hit selection 
  • Cheminformatics 
  • Medicinal chemistry 
  • Principles of open data and open-source tools
  • Assay development and optimisation 
  • Data analysis/ data reproducibility
  • Screening automation 
  • Chemical proteomics .

In this year's EU-OPENSCREEN Autumns School also representatives from the industrial sector will share their knowledge and expertise on the latest advances in HTS and test development.

Schedule

Monday - November 14, 2022

Welcome and Introduction

9:30 - 10:30

EU-OPENSCREEN ERIC Screening and Medicinal Chemistry Services

Wolfgang Fecke 

Director General EU-OPENSCREEN ERIC, Coordinator EU-OPENSCREEN-DRIVE, Germany

10:30 - 11:30

Strategies on medicinal chemistry: Drug discovery and development

Ana Martinez

Centro de Investigaciones Biológicas Margarita Salas (CSIC), Spain

11:30Break (15')

11:45 - 12:45

Making data FAIR - a great way to increase the impact of your research

Phil Gribbon

Head of Hamburg Location, Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Hamburg

12:45Lunch Break (75')

14:00 - 15:00

Hit Selection

Johannes Landskron

Norwegian Center for Molecular Medicine (NCMM) at Oslo University (UiO), Norway

 

Tuesday - November 15, 2022

09:30 - 10:30

Introduction to Cheminformatics

Daniel Svozil

Institute of Molecular Genetics of the Czech Academy of Sciences (IMG), Czech Republic

10:30 - 11:30

The European Chemical Biology Database (ECBD)

Tomas Muller

Institute of Molecular Genetics of the Czech Academy of Sciences (IMG), Czech Republic

11:30Break (15')

11:45 - 12:45

Assay Development and Compound Profiling in Drug Discovery

Thomas Lundbäck

Senior Director, Mechanistic & Structural Biology, Discovery Sciences, R&D, AstraZeneca, Sweden

12:45Lunch Break (75')

14:00 - 15:00

High throughput screening with natural products libraries

Olga Genilloud

Scientific Director Fundación MEDINA, Spain

 

Wednesday - November 16, 2022

09:30 - 10:30

Designing chemical probes for serine hydrolases

Rui Moreira

President of the European Federation for Medicinal Chemistry (EFMC), Research Institute for Medicine (imed), Portugal

10:30 - 11:30

Assay development and optimization

Pepo Brea

University of Santiago de Compostela (USC), Spain

11:30Break (15')

11:45 - 12:45

Chemical proteomics

Guillaume Médard

TUM School of Life Sciences, Technical University of Munich, Germany

12:45Lunch Break (75')
14:00 - 15:00

Quantifying Target Engagement in Cells with NanoBRET probes

Matthew Robers

Promega Corporation

 

Thursday - November 17, 2022

09:30 - 10:30

Introduction to the translational development pipeline – from idea to the patient

Rebecca Ludwig, Alicia Soler

EATRIS | European infrastructure for translational medicine

10:30 - 11:30

Mechanism of Action and Target Identification Studies

Brinton Seashore-Ludlow

Chemical Biology Consortium Sweden (CBCS)

11:30Break (15')

11:45 - 12:45

A toolkit towards the design of antimetastatic advanced therapies

Maria J. Vicent

Centro de Investigación príncipe Felipe, Spain

12:45Lunch Break (75')

14:00 - 15:00

Drug sensitivity and resistance testing

Jani Saarela

Institute for Molecular Medicine Finland (FIMM)

 

Friday - November 18, 2022

1st Session

09:30 - 10:30

Optimizing the biological profile of compounds in the drug discovery process

Sheraz Gul

Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Germany

10:30 - 11:30

General introduction to chemical biology

Mabel Loza, Maria Joao Matos 

University of Santiago de Compostela (USC), Spain

11:30Break (15')
11:45 - 12:45

Screening automation

Martin Neuenschwander 

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Germany 

12:45Lunch Break (75')
14:00 - 15:00

Using QC purity + identity assessment to enhance data reproducibility and reliability

Federica Rossella

EU-OPENSCREEN ERIC, Germany